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Best AQUARIUM FISH MEDICATIONS

At Aquarium Accessories Reviews, we take pride in our rigorous review process. Each product is handpicked based on market research, personally tested by our experienced team for functionality and durability, and evaluated for value for money. Alongside our hands-on experience, we also consider real user feedback. This meticulous approach ensures we provide honest, transparent, and comprehensive reviews to guide your aquarium accessory purchases.

We will continue to update this buyer's guide once a month or two.

The best AQUARIUM FISH MEDICATIONS in 2024 - Detailed Product Descriptions

1. Seachem Metronidazole 5gram

By Seachem Store

Seachem Metronidazole 5gram

Treats bacterial infections
For marine and freshwater use
Easy to dose, easy to use. For ornamental fish only.

2. Seachem Betta Basics 250ml

By Seachem Store

Seachem Betta Basics 250ml

Creates ideal environment both bettas and plants
Removes any chlorine, chloramine and detoxifies ammonia
Buffers to 7.0

3. Hikari Prazipro 16oz

By Hikari Store

Hikari Prazipro 16oz

Ready To Use Liquid Concentrate For Fresh Water and Marine Aquariums
Treats Flukes, Tapeworm, Flatworms, Turballarians, and Iasis
Treats 1, 920 Gallons
Highly Effective, Extremely Safe
Non-Toxic To Commonly Kept Aquarium Animals Or Plants

4. Seachem PolyGuard 100gram

By Seachem Store

Seachem PolyGuard 100gram

Country Of Origin : United States
The Package Height Of The Product Is 2.3 Inches
The Package Length Of The Product Is 4.9 Inches
The Package Width Of The Product Is 2.4 Inches

5. Mars Fishcare North America Inc. Stress Coat 4 oz. bottle

By API Store

Mars Fishcare North America Inc. Stress Coat 4 oz. bottle

Makes tap water safe
The healing power of aloe Vera
Enhances slime coat

6. Boyd Enterprises ABE16705 Chemipure Filter Media for Aquarium, 10-Ounce

By Brand: Boyd Enterprises

Boyd Enterprises ABE16705 Chemipure Filter Media for Aquarium, 10-Ounce

Crystal clear water
Stabilizes pH
Removes toxic elements
The Original Chemi-pure for over 50 years
Age range description: All Stages

7. API AQUARIUM SALT Freshwater Aquarium Salt 65-Ounce Box

By API Store

API AQUARIUM SALT Freshwater Aquarium Salt 65-Ounce Box

Contains one (1) API AQUARIUM SALT Freshwater Aquarium Salt 65-Ounce Box
Promotes fish health and disease recovery with increased electrolytes
Improves respiration for fish in freshwater aquariums
Made from evaporated sea water for all-natural results
Use when changing water, when setting up a new freshwater aquarium and when treating fish disease

9. MICROBE-LIFT XTA04 Xtreme Water Conditioner Treatment for Aquariums and Fish Tanks, 4 Ounces

By MICROBE-LIFT Store

MICROBE-LIFT XTA04 Xtreme Water Conditioner Treatment for Aquariums and Fish Tanks, 4 Ounces

FULL-FUNCTION WATER CONDITIONER: Formulated to condition and instantly "age" new water to prepare for marine life; Safe to use when setting up a new pond or aquarium, making water changes, or when adding new fish, invertebrates, amphibians, or plants
CLEANER WATER: Xtreme solution detoxifies nitrite, removes ammonia and chlorine, and destroys and removes chloramines; these properties create a cleaner environment for marine life, plants, and coral in your aquarium and fish tank
IMPROVES WATER STABILITY: By adding a multi-part skin-slime replacer, essential electrolytes, and boosting alkalinity, Xtreme creates an environment that boosts the health of your fish
PREVENTS OSMOTIC SHOCK: XTreme detoxifies heavy metals such as copper and lead by both chelation and precipitation; this process prevents exposure to osmotic shock that is often caused when new water is added
RECOMMENDATIONS: Perform regular water changes to keep the alkalinity and pH stable; Use XTreme at the standard dosage rate to eliminate and control each measured 1 mg/L, or fraction thereof, of total ammonia

10. API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle

By API Store

API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle

Contains one (1) API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle
Heals bacterial infections and repairs damaged fins, ulcers and open wounds
Contains natural, botanical tea tree extract to quickly and rapidly help fish
Helps treat newly-introduced fish to reduce risk of disease outbreak in freshwater aquariums
Use daily for a week when treating infections and for 3 days as a preventive when adding new fish

11. DrTim’s Aquatics First Defense for Freshwater Aquariums – Stress Relief & Immune System Support with Vitamins & Immunostimulants for Fish Tanks 4oz.

By Brand: DrTim's Aquatics

DrTim’s Aquatics First Defense for Freshwater Aquariums – Stress Relief & Immune System Support with Vitamins & Immunostimulants for Fish Tanks 4oz.

First Defense for Freshwater Aquarium provides stress relief & naturally supports fish immune system
Aids fish & other aquatic organisms as they adapt to new tank environments & poor water quality conditions
Contains a mixture of vitamins & immunostimulants that promote wound healing & boost immune health
Neutralizes chlorine & chloramine in water, buffers against pH changes, & detoxifies heavy metals
Use when setting-up a new aquarium, changing tank water, adding new fish & after routine maintenance

12. Seachem Matrix Bio Media 250ml

By Seachem Store

Seachem Matrix Bio Media 250ml

Supports denitrifying bacteria
Extreme surface area
No need to replace ever
The Package Weight Of The Product Is 1 Pounds

13. Ecological Laboratories Microbe-Lift Parazoryne Ready to Use Concentrate Size: 32 oz.

By Brand: Eco Labs

Ecological Laboratories Microbe-Lift Parazoryne Ready to Use Concentrate Size: 32 oz.

Keeps your fish healthy.
Herbal water conditioner for parasitic diseases.
100% natural ingredients.
Net 32 fl. oz. (946 mL) (PCON32) Treats up to 2,365 gal. (8,953 L) for 10 days.
Completely safe to use Non-toxic to animals and plants.

14. GarlicGuard, 100 mL / 3.4 fl. oz.

By Seachem Store

GarlicGuard, 100 mL / 3.4 fl. oz.

Contains 1- 100ml bottle
Garlic additive and Flavor Enhancer for freshwater and Saltwater: reef and Plant safe
All natural garlic scented odor and Flavor Enhancer for freshwater and Saltwater Fish

15. API Pimafix 4oz bottle

By API Store

API Pimafix 4oz bottle

Rapidly treats fungal infections on body and fins
Safe for delicate fresh & saltwater fish
Extracted from West Indian Bay Trees

16. API General Cure Freshwater and Saltwater Fish Powder Medication 10-Count Box

By API Store

API General Cure Freshwater and Saltwater Fish Powder Medication 10-Count Box

Contains one (1) API GENERAL CURE Freshwater and Saltwater Fish Powder Medication 10-Count Box
Rapidely eliminates parasitic fish disease.
Use for parasitic fish disease symptoms, such as gill & skin flukes, swollen abdomen, hole-in-the-head, and wasting disease, see diagnostic chart on back of carton.
Easy-to-dose packets for use in fresh and saltwater aquariums
Use 2 packets every 48 hours when symptoms of fungal diseases appear.

17. Boyd Enterprises Chemi-Pure Aquarium Filtration Media, 5.5-Ounce, Blue

By Brand: Boyd Enterprises

Boyd Enterprises Chemi-Pure Aquarium Filtration Media, 5.5-Ounce, Blue

Chemi-Pure Blue rinses clean quickly, virtually dust free
Highest quality extruded carbon and resins
Efficient and high speed adsorption rate
From the makers of The Original Chemi-pure for over 50 years
All in one filter media in a bag
Age range description: All Stages

18. Fritz Aquatics Mardel Copper Safe Treats, 1-Gallon

By Fritz Aquatics Store

Fritz Aquatics Mardel Copper Safe Treats, 1-Gallon

Treats ick, flukes, anchor worms and other parasites in fish
Will not interfere with biological filter
Will not discolor water
For use in fresh and saltwater tanks

19. API (2 Pack) Melafix Antibacterial Fish Remedy 16-Ounce Bottles

By API Store

API (2 Pack) Melafix Antibacterial Fish Remedy 16-Ounce Bottles

Contains one (1) API MELAFIX Freshwater Fish Bacterial Infection Remedy 16-Ounce Bottle
Heals bacterial infections and repairs damaged fins, ulcers and open wounds
Contains natural, botanical tea tree extract to quickly and rapidly help fish
Helps treat newly-introduced fish to reduce risk of disease outbreak in freshwater aquariums
Use daily for a week when treating infections and for 3 days as a preventive when adding new fish

21. Boyd's Chemi Pure Blue 11oz Bulk - 6 Pack

By Brand: Boyd's

Boyd's Chemi Pure Blue 11oz Bulk - 6 Pack

Reduces organics, tannins, odors, and toxins
Reduces medications, dissolved metals, phosphates and silicates
Rapidly remove organics and phosphates from your aquarium water
Raises redox
Helps stabilize pH

22. 39 Ounce Premium Laboratory Grade Super Activated Carbon with Free Media Bag Inside - AM Brand

By Brand: Aquarium Masters

39 Ounce Premium Laboratory Grade Super Activated Carbon with Free Media Bag Inside - AM Brand

Captures micro & macro organic particles
Absorbs harmful toxins and spent medication
Removes odor and discoloration
Freshwater and Marine Safe
Premium laboratory grade super activated carbon includes one free media bag

25. JOR Catappa Indian Almond Leaves, Fin Rot Treatment Betta Fish Water Conditioner Aquarium Leaves, Create Realistic River Habitat, Reduce Stress, Loved by Shrimp & Tropical Fish

By Brand: JOR

JOR Catappa Indian Almond Leaves, Fin Rot Treatment Betta Fish Water Conditioner Aquarium Leaves, Create Realistic River Habitat, Reduce Stress, Loved by Shrimp & Tropical Fish

Give a stress-free home to your pets --- You know when fish aren’t given the required environment, they come under extreme stress. Soon you will notice them hiding, white spots on their skin, scratching themselves with tank décor products, and swimming mostly on the surface. Our 60-pack miracle leaves for tropical fish by row are considered to have beneficial properties and increase fish appetite making them stress-free.
Shield Your Beautiful Betta --- More common in uncycled tanks and small bowls, fin rot begins to eat away a betta fish’s beautiful fins. Be careful not to confuse fin rot with fin biting, tearing or splitting. They are caused by physical injury from boredom, fighting or snagging sharp decor. If your betta has fin rot, you will specifically see white, red or black edges on the deteriorating fins.
Miracle Leaves Keep Betta In An Optimal State --- Fin rot, sometimes called fin melt or tail rot, is fairly common. It is caused by things that exist in your aquarium water. These undesirables start becoming a menace when your betta has a weak growth or when you are raising a vulnerable fry. You can keep your betta fish in optimal health by adding these phenomenal leaves.
Other Medication Not Required --- If you spot fin rot before it gets too severe, you can stop the spread using wholesome Indian almond leaves. Catappa leaves help your betta fish to get in better shape faster. It is best to keep catappa leaves in your tank because once fin rot becomes too bad, it will require medication.
World Class Zoo Aquarium --- Zoo aquariums do their best to recreate each resident fish’s native habitat. Why? Because it helps the inhabitants thrive. That means less stress, longer life, and better breeding. It also means you can experience your bettas, cichlids, eels, and catfish living and behaving as they would in the wild. Adding JOR Mini Catappa Leaves will help you recreate your pet’s native habitat just like zoos and aquariums do.

26. API Liquid Super ICK Cure Fish Remedy, Freshwater and Saltwater Fish Medication 4 fl oz(Pack of 1) & Aquarium Salt Freshwater Aquarium Salt 33-Ounce Box

By API Store

API Liquid Super ICK Cure Fish Remedy, Freshwater and Saltwater Fish Medication 4 fl oz(Pack of 1) & Aquarium Salt Freshwater Aquarium Salt 33-Ounce Box

Product 1: Contains one (1) API LIQUID SUPER ICK CURE Freshwater and Saltwater Fish Medication 4-Ounce Bottle
Product 1: Treats "ich" white spot disease in fish and secondary bacterial fish infections
Product 1: Quickly kills ich parasite, typically within 24 hours of first dose
Product 1: Use only in freshwater and saltwater aquariums not with reef aquariums
Product 2: Contains one (1) API AQUARIUM SALT Freshwater Aquarium Salt 33-Ounce Box
Product 2: Promotes fish health and disease recovery with increased electrolytes
Product 2: Improves respiration for fish in freshwater aquariums
Product 2: Made from evaporated sea water for all-natural results

27. Fritz MetroCleanse - 20 pk

By Fritz Aquatics Store

Fritz MetroCleanse - 20 pk

Easy Packet Dosing System
Safe for Fresh and Saltwater Systems
Treats Ich, Hexamita, and Oodinium
Effective Against Internal and External Infections

28. Seachem Purigen Organic Filtration Resin - Fresh and Saltwater 100 ml & Boyd Enterprises ABE16742 Chemipure Elite for Aquarium, 6.5-Ounce

By Seachem Store

Seachem Purigen Organic Filtration Resin - Fresh and Saltwater 100 ml & Boyd Enterprises ABE16742 Chemipure Elite for Aquarium, 6.5-Ounce

Product 1: FILTRATION: Purigen ranges in color from almost white (cream) to light yellow. Seachem Purigen is not a mixture of ion exchangers or adsorbents, but a unique macro-porous synthetic polymer that removes soluble and insoluble impurities from water.
Product 1: SELECTIVITY: Seachem Purigen is an organic filtration resin that works hard to remove nitrogenous compounds and waste produced by fish, corals, and even plants, making your water crystal clear.
Product 1: CAPACITY: Being both spherical and macroreticular, Seachem Purigen has microscopic pores that increase its usable surface area to many times that of a purely spherical resin.
Product 1: REGENERATION: Once Seachem’s Purigen is exhausted, it can be regenerated with a solution of bleach and water. The bleach will literally “burn off” the organics that have been removed from the tank.
Product 2: Crystal clear water
Product 2: Removes phosphates, silicates, odors and color-causing's dissolved organic molecules.
Product 2: Removes excess nutrients to limit algae growth
Product 2: The Original Chemi-pure for over 50 years

29. API FIN & Body Cure Freshwater Fish Powder Medication 10-Count Box & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

By API Store

API FIN & Body Cure Freshwater Fish Powder Medication 10-Count Box & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

Product 1: Contains one (1) API FIN and BODY CURE Freshwater Fish Powder Medication 10-Count Box
Product 1: Treats body slime, eye cloud, fin and tail rot, open red sores, gill disease, and hemorrhagic septicemia
Product 1: Causes slight discoloration of water that can be fixed by adding activated charcoal
Product 1: Use only in freshwater aquariums
Product 2: Contains one (1) API STRESS COAT Aquarium Water Conditioner 16-Ounce Bottle
Product 2: Makes tap water safe and protects fish with dual-action formula
Product 2: Removes chemicals from tap water that are harmful to fish
Product 2: Replaces fish’s protective coat damaged by handling, shipping or fish fighting with healing power of Aloe Vera extract

30. API MELAFIX Freshwater Fish Bacterial Infection Remedy 16-Ounce Bottle & Liquid Super ICK Cure Fish Remedy, Freshwater and Saltwater Fish Medication 4 fl oz(Pack of 1)

By API Store

API MELAFIX Freshwater Fish Bacterial Infection Remedy 16-Ounce Bottle & Liquid Super ICK Cure Fish Remedy, Freshwater and Saltwater Fish Medication 4 fl oz(Pack of 1)

Product 1: Contains one (1) API MELAFIX Freshwater Fish Bacterial Infection Remedy 16-Ounce Bottle
Product 1: Heals bacterial infections and repairs damaged fins, ulcers and open wounds
Product 1: Contains natural, botanical tea tree extract to quickly and rapidly help fish
Product 1: Helps treat newly-introduced fish to reduce risk of disease outbreak in freshwater aquariums
Product 2: Contains one (1) API LIQUID SUPER ICK CURE Freshwater and Saltwater Fish Medication 4-Ounce Bottle
Product 2: Treats "ich" white spot disease in fish and secondary bacterial fish infections
Product 2: Quickly kills ich parasite, typically within 24 hours of first dose
Product 2: Use only in freshwater and saltwater aquariums not with reef aquariums

31. API FIN & Body Cure Freshwater Fish Powder Medication 10-Count Box & Aquarium Salt Freshwater Aquarium Salt 16-Ounce Box

By API Store

API FIN & Body Cure Freshwater Fish Powder Medication 10-Count Box & Aquarium Salt Freshwater Aquarium Salt 16-Ounce Box

Product 1: Contains one (1) API FIN and BODY CURE Freshwater Fish Powder Medication 10-Count Box
Product 1: Treats body slime, eye cloud, fin and tail rot, open red sores, gill disease, and hemorrhagic septicemia
Product 1: Causes slight discoloration of water that can be fixed by adding activated charcoal
Product 1: Use only in freshwater aquariums
Product 2: Contains one (1) API AQUARIUM SALT Freshwater Aquarium Salt 16-Ounce Box
Product 2: Promotes fish health and disease recovery with increased electrolytes
Product 2: Improves respiration for fish in freshwater aquariums
Product 2: Made from evaporated sea water for all-natural results

32. API Liquid Super ICK Cure Freshwater and Saltwater Fish Medication 16-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

By API Store

API Liquid Super ICK Cure Freshwater and Saltwater Fish Medication 16-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

Product 1: Contains one (1) API LIQUID SUPER ICK CURE Freshwater and Saltwater Fish Medication 16-Ounce Bottle
Product 1: Treats "ich" white spot disease in fish and secondary bacterial fish infections
Product 1: Quickly kills ich parasite, typically within 24 hours of first dose
Product 1: Corals and invertebrates may be sensitive to this medication. We do not recommend usage in reef aquariums or any freshwater or saltwater aquarium with invertebrates.
Product 2: Contains one (1) API ACCU-CLEAR Freshwater Aquarium Water Clarifier 8-Ounce Bottle
Product 2: Clears cloudy aquarium water
Product 2: Clumps floating particles into large clusters that can be easily removed by an aquarium filter
Product 2: Works fast and maximizes filter efficiency

33. API Liquid Super ICK Cure Freshwater and Saltwater Fish Medication 16-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

By API Store

API Liquid Super ICK Cure Freshwater and Saltwater Fish Medication 16-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

Product 1: Contains one (1) API LIQUID SUPER ICK CURE Freshwater and Saltwater Fish Medication 16-Ounce Bottle
Product 1: Treats "ich" white spot disease in fish and secondary bacterial fish infections
Product 1: Quickly kills ich parasite, typically within 24 hours of first dose
Product 1: Corals and invertebrates may be sensitive to this medication. We do not recommend usage in reef aquariums or any freshwater or saltwater aquarium with invertebrates.
Product 2: Contains one (1) API STRESS COAT Aquarium Water Conditioner 16-Ounce Bottle
Product 2: Makes tap water safe and protects fish with dual-action formula
Product 2: Removes chemicals from tap water that are harmful to fish
Product 2: Replaces fish’s protective coat damaged by handling or fish fighting with healing power of Aloe Vera extract

34. API MELAFIX Freshwater Fish Bacterial Infection Remedy 8-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

By API Store

API MELAFIX Freshwater Fish Bacterial Infection Remedy 8-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

Product 1: Contains one (1) API MELAFIX Freshwater Fish Bacterial Infection Remedy 8-Ounce Bottle
Product 1: Heals bacterial infections and repairs damaged fins, ulcers and open wounds
Product 1: Contains natural, botanical tea tree extract to quickly and rapidly help fish
Product 1: Helps treat newly-introduced fish to reduce risk of disease outbreak in freshwater aquariums
Product 2: Contains one (1) API STRESS COAT Aquarium Water Conditioner 16-Ounce Bottle
Product 2: Makes tap water safe and protects fish with dual-action formula
Product 2: Removes chemicals from tap water that are harmful to fish

35. Seachem StressGuard Slime Coat Protection - Stress and Toxic Ammonia Reducer 500 ml & Stability - for Freshwater and Marine Aquariums 250ml

By Seachem Store

Seachem StressGuard Slime Coat Protection - Stress and Toxic Ammonia Reducer 500 ml & Stability - for Freshwater and Marine Aquariums 250ml

Product 1: Premium slime coat protection
Product 1: Promotes healing in wounds
Product 1: Will not coat resins or clog filter
Product 1: Protein active colloids
Product 2: TANK STABILIZATION: Seachem Stability will rapidly and safely establish the aquarium biofilter in freshwater and marine systems, thereby preventing the #1 cause of fish death: "new tank syndrome".
Product 2: TREATMENT: Stability is formulated specifically for the aquarium and contains a synergistic blend of aerobic, anaerobic, and facultative bacteria which facilitate the breakdown of waste organics, ammonia, nitrite, and nitrate.
Product 2: BACTERIA GROWTH: The necessary conditions for the growth of Stability's bacterial strains encompass a very broad range. When other bacteria begin to die off (usually from high organic loads caused by the unknown death of an organism), Stability simply becomes more effective.
Product 2: USE: Shake Seachem Stability well before use and turn off UV/ozone filter. Use 1 capful (5 mL) for each 40 L (10 US gallons) on the first day with a new aquarium. Then use 1 capful for each 80 L (20 US gallons) daily for 7 days. Fish and other aquatic species may be introduced at any time as long as the dosage is maintained for 7 days.

36. API MELAFIX Freshwater Fish Bacterial Infection Remedy 16-Ounce Bottle & Aquarium Salt Freshwater Aquarium Salt 65-Ounce Box

By API Store

API MELAFIX Freshwater Fish Bacterial Infection Remedy 16-Ounce Bottle & Aquarium Salt Freshwater Aquarium Salt 65-Ounce Box

Product 1: Contains one (1) API MELAFIX Freshwater Fish Bacterial Infection Remedy 16-Ounce Bottle
Product 1: Heals bacterial infections and repairs damaged fins, ulcers and open wounds
Product 1: Contains natural, botanical tea tree extract to quickly and rapidly help fish
Product 1: Helps treat newly-introduced fish to reduce risk of disease outbreak in freshwater aquariums
Product 2: Contains one (1) API AQUARIUM SALT Freshwater Aquarium Salt 65-Ounce Box
Product 2: Promotes fish health and disease recovery with increased electrolytes
Product 2: Improves respiration for fish in freshwater aquariums
Product 2: Made from evaporated sea water for all-natural results

author img Lucas Carter

Our Editor-in-Chief, Lucas Carter, brings over twenty years of hands-on experience in the world of aquaristics. He is not just an expert in aquarium keeping but also a passionate advocate for the hobby. Lucas's extensive knowledge of aquarium accessories, understanding of different aquatic ecosystems, and a keen eye for product quality set the standard for our reviews. His personal commitment is to guide both novice and experienced aquarium enthusiasts through the vast ocean of products, helping them create the ideal environment for their aquatic friends.